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Applications of Nanosuspensions

Articles | Pharmaceutics | Suspensions    Date: 02-Jun-2011  Views: 2292
Nanosuspension technology is applicable to all poorly soluble drugs and an outstandingfeature of this technology is its simplicity.
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Characterization of Nanosuspensions

Articles | Pharmaceutics | Suspensions    Date: 02-Jun-2011  Views: 2489
A critical parameter that defines the quality and physicochemical behavior ofnanosuspensions is the particle size distribution. The mean particle size and widthof distribution can be determined using photon correlation spectroscopy (PCS),laser diffraction (LD), and coulter counter techniques.
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Preparation of NanoSuspensions

Articles | Pharmaceutics | Suspensions    Date: 02-Jun-2011  Views: 2009
Nanosuspensions can be produced by bottom-up or top-down techniques. In thecase of bottom-up technique, the strategy is to build particles from their constituentunits, i.e., molecules, atoms. Bottom-up technique is a classical precipitation processin which the drug is dissolved in a solvent, which is subsequently added to anonsolvent to precipitate the drug crystals.
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Introduction of Nanosuspensions

Articles | Pharmaceutics | Suspensions    Date: 02-Jun-2011  Views: 2168
Many of the marketed drugs and a large proportion (40%) of potentially bioactivemolecules from drug discovery are poorly soluble in aqueous and nonaqueous solvents(Lipinski 2002).
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Important Considerations in Formulation of Suspension

Articles | Pharmaceutics | Suspensions    Date: 02-Jun-2011  Views: 3667
Formulation of a pharmaceutical suspension requires a knowledge of the propertiesof both the dispersed phase and the dispersion medium. The material for the formulationof suspensions should be carefully selected keeping in mind the route ofadministration, intended application, and possible adverse effects.
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Introduction of Pharmaceuctical Suspensions

Introduction of Pharmaceuctical Suspensions

Articles | Pharmaceutics | Suspensions    Date: 02-Jun-2011  Views: 2308
Suspensions are a class of dispersed system in which a finely divided solid isdispersed uniformly in a liquid dispersion medium (Nash 1988). Suspensions can beclassified as coarse or colloidal dispersion, depending on the size of particles.
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